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Can AI build custom ‘n-of-1’ drugs faster? Maybe not yet, new case study suggests

Jason Mast (STAT News)

May 13, 2024


Two years ago, Yiwei She was searching desperately for someone to build a drug for her newborn son, Leo. Leo was born with a very small head, a symptom of many severe diseases. After a seizure at two months, doctors sequenced his genome and found a single misspelling in a gene called TNPO2.


Little was known about the gene, except that it was involved in neurodevelopment. The most recent paper the family found was in fruit flies. Only one other boy in the world had been identified with Leo’s mutation. She contacted the family.


YiWei She with her son Leo, courtesy Yiwei She


And we found out from the family that at about age 3, the other boy stopped kind of making progress developmentally,” She said. “We were like, time is of the essence.





Mast, J. (2024, May 14). Can AI build custom ‘n-of-1’ drugs faster? Maybe not yet, new case study suggests. STAT. https://www.statnews.com/2024/05/13/ai-custom-nof1-drugs-new-study/

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