Updated October 15, 2023
Research technician DCRT: Would you like to develop genetic therapies for patients with rare neurological disorders? Are you interested in using new cellular modelling systems to study human disease? If you are interested in joining a very young, international team at the Dutch Center for RNA Therapeutics, visit LUMC for more information.
Synofzik Lab: Translational Genomics of Neurodegenerative Diseases (ataxias, frontotemporal dementia, early-onset Alzheimer's dementia, amyotrophic lateral sclerosis, rare genetic neurodegenerative diseases). Research priorities of our group are: translational pipeline from gene to targeted mechanistic therapy, with the following core clusters: next-generation sequencing genomics (WES, WGS, RNAseq). Fluid biomarkers in CSF and blood. Sensor-based digital motor outcomes. Clinical outcome parameters and natural history studies. Innovative first-in-human therapy studies, e.g. with customized n-of-1 antisense oligonucleotides (ASOs).